Application

Research Sub CategoryNeurodegenerative Diseases

Western blot: 1:100-1:2,000
Immunocytochemistry: 1:100-1:2,000
Immunohistochemistry: 1:100-1:2,000
Optimal working dilutions must be determined by end user.

Research CategoryNeuroscience

Detect Beclin 1 using this Anti-Beclin 1 Antibody validated for use in WB, IC, IH.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development, differentiation, growth regulation and tissue remodeling in multicellular organisms. Beclin 1 is a BCL-2 interacting protein and this protein was shown to play a role in the promotion of autophagy.

Immunogen

Synthetic peptide corresponding to the C-terminus of human Beclin 1 protein.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Linkage

Replaces: MABN16

Physical form

Lyophilized. Reconstitute with 50 µL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative.

Serum

Specificity

Beclin 1 [Coiled-coil myosin-like BCL2-interacting protein, BECN1].

Storage and Stability

Maintain lyophilized material frozen at -20°C to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability.